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These metabolites demonstrate dual neuroimmune regulatory capacity: indole derivatives activate aryl hydrocarbon receptor (AhR) signaling to promote anti-inflammatory cytokine production (Zhao et al., 2024), while kynurenine accumulation correlates with chronic inflammatory and neuropsychiatric disorders ( The gut-lung axis operationalizes these metabolites through systemic immunomodulation

Kaplan et al., 2011)

Furtado et al

N-Acetylcysteine N-acetylcysteine (NAC) as an antioxidant acts as a reductant of disulfide bonds, a scavenger of ROS and a precursor for glutathione biosynthesis [108]